黄芪保护血管内皮细胞作用机制研究进展

张小鸿,徐先祥,汪宁卿

中国药学杂志 ›› 2013, Vol. 48 ›› Issue (18) : 1526-1530.

PDF(779 KB)
PDF(779 KB)
中国药学杂志 ›› 2013, Vol. 48 ›› Issue (18) : 1526-1530. DOI: 10.11669/cpj.2013.18.003
综述

黄芪保护血管内皮细胞作用机制研究进展

  • 张小鸿,徐先祥,汪宁卿
作者信息 +

Progress of Studies on Protective Mechanism of Radix Astragali in Vascular Endothelial Cells

  • ZHANG Xiao-hong, XU Xian-xiang, WANG Ning-qing
Author information +
文章历史 +

摘要

目的综述黄芪保护血管内皮细胞作用机制研究进展。方法查阅近年来国内外相关文献,对益气中药黄芪及其有效成分保护血管内皮细胞作用机制研究进行归纳总结。结果黄芪及其有效成分可通过促进内皮细胞增殖,抑制细胞凋亡,促进血管生成,促进一氧化氮合成,干预细胞黏附,改善血管舒张功能,调节内皮活性物质分泌,抗氧化应激等作用,发挥保护血管内皮细胞功能,对于心血管疾病等涉及内皮功能障碍的多种疾病显示重要治疗价值。结论黄芪及其多种成分对血管内皮细胞具有多靶点的保护作用,总结黄芪保护血管内皮细胞作用的机制和特点对于探讨黄芪“益气”功效在血瘀证防治中的应用具有重要的理论价值。

Abstract

OBJECTIVE To review the progress of studies on protective mechanism of Radix Astragali in vascular endothelial cells. METHODS The summarization of the progress of studies on protective mechanism of tonifying qi chinese medicine Radix Astragali as well as its effective components in vascular endothelial cells were based on referring to the related literature in recent years. RESULTS The protective function of Radix Astragali as well as its effective components in vascular endothelial cells in means of promoting endothelial cells proliferation, inhibiting cells apoptosis, promoting angiogenesis, boosting nitric oxide composition, intervening cells adhesion, ameliorating vasodilatation function, regulating endothelial active substance secretion, antioxidation and so on, revealed significance therapeutic value in cardiovascular diseases and other diseases with endothelum disfunction. CONCLUSION Because of the multiple-targeted protective effect of Radix Astragali in vascular endothelial cells, the summarization of the protective mechanism and character of Radix Astragali in vascular endothelial cells had possessed of vital theoretical value with regard to exploring “tonifying qi” effective of Radix Astragali in prevention and treatment of blood stasis.

关键词

黄芪 / 血管内皮细胞 / 作用机制

Key words

Radix Astragali / vascular endothelial cells / mechanism

引用本文

导出引用
张小鸿,徐先祥,汪宁卿. 黄芪保护血管内皮细胞作用机制研究进展[J]. 中国药学杂志, 2013, 48(18): 1526-1530 https://doi.org/10.11669/cpj.2013.18.003
ZHANG Xiao-hong, XU Xian-xiang, WANG Ning-qing. Progress of Studies on Protective Mechanism of Radix Astragali in Vascular Endothelial Cells[J]. Chinese Pharmaceutical Journal, 2013, 48(18): 1526-1530 https://doi.org/10.11669/cpj.2013.18.003
中图分类号: R285   

参考文献

[1] TOYA S P, MALIK A B. Role of endothelial injury in disease mechanisms and contribution of progenitor cells in mediating endothelial repair . Immunobiolog, 2012, 217(5): 569-580.[2] XIONG Y C, HONG X P, CHEN Z B, et al. Effect of astragalus membranaceus on the pattern of vascular endothelial cells of diabetic rats . Chin Arch Tradit Chin Med (中医药学刊), 2004, 10(22): 1859-1860.[3] WEI X J, WU Y N, JIANG H. Effects of astragalus on expression of Apelin /APJ in human umbilical vein endothelial cells exposed to high glucose . J Shandong Univ(Med Ed) (山东大学学报:医学版), 2010, 40(4): 10-14.[4] ZHANG L, HU G, SUO Z W, et al. Effect of astragalus polysacc harides on prolifer ation of rat Intestinal mucosa microvascular endothelial cells in vitro. China Anim Husb Vet Med (中国畜牧兽医), 2009, 36(3): 80-83.[5] SHU H, WANG J Q, WANG Y, et al. Effect of calycosin extracted from astragalus membranaceus on trans-differentiation of endothelial cells induced by transforming growth factor-β1 . China J Tradit Chin Med Pharm (中华中医药杂志), 2012, 27 (3): 753-755.[6] ZHANG Y I, HU G, LIN H C, et al. Radix astragali extract promotes angiogenesis involving vascular endothelial growth factor receptor-related phosphatidylinositol 3-Kinase/Ak t-dependent pathway in human endothelial cells . Phytother Res, 2009, 23(9): 1205-1213.[7] ZHANG L, YANG Y, WANG Y, et al. Astragalus membranaceus extract promotes neovascularisation by VEGF pathway in rat model of ischemic injury . Pharmazie, 2011, 66(2): 144-150.[8] ZHANG Y, HU G, LI S, et al. Pro-angiogenic activity of astragaloside IV in HUVECs in vitro and zebrafish in vivo . Mol Med Report, 2012, 5(3): 805-811.[9] ZHANG L, LIU Q, LU L, et al. Astragaloside IV stimulates angiogenesis and increases hypoxia-inducible factor-1α accumulation via phosphatidylinositol 3-kinase/Akt pathway . J Pharmacol Exp Ther, 2011, 338(2): 485-491. TANG J Y, LI S, LI Z H, et al. Calycosin promotes angiogenesis involving estrogen receptor and mitogen-activated protein kinase (MAPK) signaling pathway in zebrafish and HUVEC . PLoS One, 2010, 5(7): 11822. LI S, LOU S, LEI B U, et al. Transcriptional profiling of angiogenesis activities of calycosin in zebrafish . Mol Biosys, 2011, 7(11): 3112-3121. DING J S. Influence of astragalus on human umbilical vein endothelial cells affected by advanced glycosylation end products . Liaoning J Tradit Chin Med (辽宁中医杂志), 2011, 38(8): 1672-1674. WANG S, FENG Y, WANG L Y, et al. The effect of polysaccharide from radix astragalion cells survival against oxygen glucose deprivation and phosphorylation of Akt . Pharm Biotechnol (药物生物技术), 2011, 18(4): 288-290. TANG D, HE B, ZHENG Z G, et al. Inhibitory effects of two major isoflavonoids in radix astragali on high glucose-induced mesangial cells proliferation and AGEs-induced endothelial cells apoptosis . Planta Med, 2011, 77(7): 729-732. LIANG L S, SONG R X. Protecti ve effect of astragalus flavone of Gansu on endothelial cells apoptosis induced by angiotensin in culture . Chin Pharmacol Bul (中国药理学通报), 2006, 22 (12): 1505-1509. SONG R X, YU J, LIANG L S, et al. Protective effects of isoflavones from Astragalus membranaceus on apoptosis of vascular endothelial cells . J Lanzhou Univ (Med Sci) (兰州大学学报:医学版), 2007, 33(1): 43-47. SHI F G, YANG Z G, DI G P, et al. Express of Fas/FasL system and apoptosis in lung tissue in scalded mouse after treating with ecin . Chin J Crit Care Med (中国急救医学), 2001, 21(10): 559-561. YOU Y, DUAN Y, LIU S W, et al. Anti-atherosclerotic function of astragali radix extract: Downregulation of adhesion molecules in vitro and in vivo . BMC Complement Altern Med, 2012, 12: 54. YANG G F, LIU G X, DONG G X. Effect of astragaloside on adhesion of human umbilical vein endothelial cells and polymorphonuclear neutrophils and expression of nuclear factor kappa B under hypoxia/reoxygenation condition . J Clin Rehabil Tissue Eng Res (中国组织工程研究与临床康复), 2008, 12(15): 2843-2846. ZHANG W J, HUFNAG P, BINDER B R, et al. Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression . Thromb Haemost, 2003, 5(90): 904-914. XU B, ZHU H Y, GAO Y H. Influences of astragalus polysaccharides on genetic transcription of P-selectin and E-selectin in human cardiac microvascular endothelial cells after ischemia-reperfusion injury . J Beijing Univ Tradit Chin Med (北京中医药大学学报), 2011, 34(3): 177-180. LI M R, YU Y R, DENG G. Astragalus membranaceus improves endothelial-dependent vasodilator function in obese rats . J South Med Univ (南方医科大学学报), 2010, 30(1): 7-10. WANG Y J, YU Y R. Protective effects of astragalus membranaceus on free fatty acid-induced vascular endothelial cell dysfunction . J Sichuan Univ (Med Sci Ed) (四川大学学报:医学版), 2011, 42 (1): 48-51. ZHANG B Q, HU S J, QIU L H, et al. Effects of astragalus membranaceus and its main components on the acute phase endothelial dysfunction induced by homocysteine . Vascul Pharmacol, 2007, 46(4): 278-285. ZHANG N, WANG X H, MAO S L, et al. Astragaloside IV improves metabolic syndrome and endothelium dysfunction in fructose-fed rats . Molecules, 2011, 16(5): 3896-3907. QIU L H, XIE X J, ZHANG B Q. Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation . Biol Pharm Bull, 2010, 33(4): 641-646. ZHANG W D, ZHANG C, WANG X H, et al. Mechanisms underlying vasorelaxant action of astragaloside IV in isolated rat aortic rings . Clin Exp Pharmacol Physiol, 2007, 34(5-6): 387-392. WU J H, LI Q, WU M Y, et al. Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways . J Nutr Biochem, 2010, 21(7): 613-620. ZHANG X Y, HUANG N, MA L J, et al. Protective effects of APS-A1 on blood vessel endothelium function induced by isofenphos-methyl . J Anhui Agr Sci (安徽农业科学), 2012, 40 (22): 11243-11244, 11374. SONG J Y, MENG L Q, LI X M. Therapeutic application and prospect of astragalus membranaceus and angelica sinensis in treating renal microvascular lesions . Chin J Integr Tradit Chin West Med (中国中西医结合杂志), 2008, 28 (9): 859-861. SONG R X, YU J, YANG L L, et al. Regulation effect of calycosin extracted from astragalus membranaceus of Gansu province on the expressions of ACE/ACE2 in vascular endothelial cells . Chin Pham J (中国药学杂志), 2008, 43 (8): 594-597. YANG C C, MA Z C. Effect of astragalus membranaceus and on plasminogen activator inhibitor-1 in cultured endothelial cell . Acta Acad Med Mil Tert (第三军医大学学报), 2010, 32(11): 1149-1151. DUAN S B, YU L, LIU Y, et al. Influence of astragalus on vascular endothelial cells injury in rat models of multiple organ dysfunction syndrome . Chin J Mod Med (中国现代医学杂志), 2012, 22(1): 5-8. BIAN Y Y, LI P. Study on scavenging activities for superoxide anion radicals and structure-activity relationship of flavonoids from Astragalus membranaceus (Fish.) Bge. var. mongholicus (Bge.) Hsiao . Chin Pham J (中国药学杂志), 2008, 43 (4): 256-259. ZHANG J J, LIU Y Z, ZHOU Y B. The effect of astragalus medicated serum on cell viability of oxidative injured model of H2O2 induced HUVEC . Inf Tradit Chin Med (中医药信息), 2011, 28(2): 19-21. ZENG G A, CHEN Y Y, LI B. The effect of astragalus polysaccharide on the function of endothel ial cells of in rabbits with atherosclerosis . Chin J Integr Med Cardio Cerebrovas Dis (中西医结合心脑血管病杂志), 2010, 8(10): 1206-1208. YI Y L, LI P, LU G Z, et al. Protective effects of APS-A3 on blood vessel endothelium function induced by paraoxon . Lishizhen Med Mater Med Res (时珍国医国药), 2011, 22(3): 583-585. BAO C Y, ZHENG M, ZHAO J. Effect of astragalus on heavy load training on rats endothelium and myocardial ultrastructure . Chin J Sports Med (中国运动医学杂志), 2006, 25(1): 87-89. LIU J C, AN C S, WANG J F, et al. Influence of radix astragalion nitric oxide and endothelin-1 in pulmonary tissue in hypoxemic pulmonary hypertension in rats . Chin J Pediatr (中华儿科杂志), 2006, 44(1): 46-48. ZHANG J F, WANG G H, CAO P, et al. Effects of astragalus injection on blood NO and ET of rats with early diabetes nephropathy . Lishizhen Med Mater Med Res (时珍国医国药), 2007, 18(4): 831-832. SHI H L, LIU Y, MA C L, et al. Effect of astragaloside IV on relaxation and molecule mechanism in isolated rat aortic rings from hypertensive rats . Chin J New Drugs Clin Rem (中国新药与临床杂志) , 2009, 28(12): 905-910. XU H S, WU Q, XIE X Y, et al. Effect of astragalus polysaccharides on peripheral endothelial progenitor cells via PI3K/Akt/eNOS signal pathway in patients with type 2 diabetes . J Clin Rehabilit Tissue Eng Res (中国组织工程研究与临床康复), 2011, 15(23): 4272-4276. YOU Y, DUAN Y, ZHANG X L, et al. Effects of astragali radix extract on the vascular cell adhesion molecule-1 expression of mice vascular endothelial cell induced by tumor necrosis factor-α . Chin J Arterioscler (中国动脉硬化杂志), 2011, 19(3): 187-189. YE Z B, WANG F J, ZHANG G Q, et al. Effects of astragalus membranaceus injection on TNF-α induced release of inflammatory factors from HUVECs and the molecular mechanisms . J South Med Univ (南方医科大学学报), 2009, 29(6): 1137-1140. LIANG S T, LI J Z. Effect and mechanism of radix astragali injection on production of inflammatory factors induced by lipopolysaccharide in human umbilical vein endothel ial cells . Chin J Clin Pharmacol Ther (中国临床药理学与治疗学), 2011, 16 (6): 611-616. LIU P, ZHU H Y, GAO Y H, et al. Effect of astragalus polysaccharides on p38MAPK signaling path and gene translation of cardiac microvascular endothelial cell adhesion molecules induced by TNF-α . World Chin Med (世界中医药), 2011, 6(3): 263-265. LI H B, GE Y K, ZHANG L, et al. Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells . Life Sci, 2006, 79(12): 1186-1193. FAN Y, WU D Z, GONG Y Q, et al. Effects of calycosin on the impairment of barrier function induced by hypoxia in human umbilical vein endothelial cells . Eur J Pharmacol, 2003, 481(1): 33-40. LI X, JIANG P. Vascular endothelial cell damage and blood stasis syndrome . Chin J Integr Tradit Chin West Med (中国中西医结合杂志), 2000, 20(2): 154-155.

基金

国家自然科学基金项目(30600821);华侨大学中央高校基本业务费“福建省杰出青年基金培育计划”专项(JB-SJ1012)
PDF(779 KB)

Accesses

Citation

Detail

段落导航
相关文章

/